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Study Of Protein Folds Offers Insight Into Metabolic Evolution

âœThe most ancient (protein) molecules were involved in the interconversion of nucleotides. But they were not synthesizing them,â Caetano-Anollés said. âœWe see that all the enzymes that were involved in purine synthesis, for example, were very recent. Since these first proteins benefited the formation of building blocks for the primitive RNA world, it makes a lot of sense that weâ™ve found this origin encased in nucleotide metabolism.â

Study Of Protein Folds Offers Insight Into Metabolic Evolution

âœWe are interested in how structure evolves, not how organisms evolve,â said professor of crop sciences Gustavo Caetano-Anollés, principal researcher on the study, which was co-written by graduate student Hee Shin Kim and emeritus professor of cell and developmental biology Jay E. Mittenthal. âœWe are using the techniques of phylogenetic analysis that systematicists used to build the tree of life, and we are applying it to a biochemical problem, a systems biology problem.â

âœThe most ancient (protein) molecules were involved in the interconversion of nucleotides. But they were not synthesizing them,â Caetano-Anollés said. âœWe see that all the enzymes that were involved in purine synthesis, for example, were very recent. Since these first proteins benefited the formation of building blocks for the primitive RNA world, it makes a lot of sense that weâ™ve found this origin encased in nucleotide metabolism.â

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